The prostate is a
small gland about the size of a walnut situated
at the base of the bladder. It is only found
in men and secretes a white fluid called
semen which mixes with sperm when a man
ejaculates. Around 20,000 new cases of prostate
cancer are diagnosed each year in the UK.
It is rare below the age of 45 but quite
common in men over 80. It is an unusual
cancer because in some (usually older men)
it affects only a small area of the prostate
and grows so slowly it may never need treatment
and does not cause symptoms. In others (usually
younger men) it causes more symptoms and
can spread outside the prostate (usually
to the bones) if the cancer is more aggressive.
The cause is unknown,
although men who have a brother or father
with prostate cancer are at a slightly higher
risk. It is seen more commonly in Afro-Caribbean
and African-American men compared to whites
and is rare among men in the Far East.
Vegetarians are half
as likely to get prostate cancer than meat
eaters. This supports scientific theory
that selenium and lycopenes (found in vegetables, particularly
tomatoes) offer protection against prostate
cancer.
Treatment
There are many different
treatments for prostate cancer and deciding
what is right is not always straight forward,
as there is a balance between treatment
and side effects. Urologists often discuss
individual cases with other doctors called
Oncologists (specialists in treating cancer)
as there are many issues to consider. The
type of treatment offered depends on the
grade and stage of the cancer (how aggressive
it is and whether it has spread outside
the prostate), the age and general health
of the man affected. There are four main
types of treatment:
‘Watchful Waiting’
– men are seen regularly and have
PSA blood tests, but no treatment is given
unless they deteriorate. Useful for small,
slow growing non-aggressive cancers in elderly
men where the cancer does not affect their
life expectancy.
Radical Surgery (prostatectomy)
– an operation in which the whole
prostate is removed. Men are followed up
afterwards with regular PSA blood tests
to make sure the cancer does not come back.
It is only effective in younger men who
have aggressive small cancers that have
not spread outside of the prostate. It is
a major operation with serious side effects.
Many men afterwards are impotent (unable
to get an erection) and a minority will
be incontinent. Despite this, some men prefer
this treatment as the long-term outcome
is good.
Radiotherapy –
X-rays are delivered to the prostate either
through the skin from the outside (external
beam) or by placing small radioactive seeds
directly in the prostate (brachytherapy)
to kill cancer cells. It is effective on
the same group of men as surgery and often
a decision between the two has to be made
as the long-term results are similar. The
risk of impotence and incontinence after
radiotherapy is less than surgery, and radiotherapy
has it’s own side effects including
skin damage and bowel problems.
Hormone Therapy –
Prostate cancer cells are very sensitive
to the male hormone testosterone. By removing
this hormone the cancer cells shrink and
don’t grow, remaining static. Testosterone
levels can be lowered by castration (surgical
removal of both testicles - this is rare
nowadays) or more commonly, by tablets or
monthly injections. Men with metastatic
prostate cancer i.e. cancer that has spread
either locally (around the area of the prostate)
or to distant areas (usually the bones)
are most suitable for hormone therapy. It
is sometimes used before radiotherapy to
shrink the cancer down. It can be very effective
in controlling the pain associated with
cancer which has spread to the bones, and
in many men controls their cancer sufficiently
for them to live a normal life. Side effects
can include lowered libido, possible impotence,
hot sweats and breast enlargement, but generally
it is tolerated well.
In some circumstances
combinations of different treatments are
used. It is important for men with prostate
cancer to be informed of all the benefits
and risks when deciding what treatment is
best for them.
In some circumstances
combinations of different treatments are
used. It is important for men with prostate
cancer to be informed of all the benefits
and risks when deciding what treatment is
best for them.
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